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Medications to combat obesity

These medications are a tool against obesity, but they are not a magic solution nor do they exempt you from following diet and exercise guidelines.

Obesity is a chronic disease that affects millions of people in the world and is associated with an increased risk of suffering from other pathologies such as diabetes, hypertension, cardiovascular diseases or cancer. Therefore, it is important to have effective and safe treatments that help people with obesity lose weight and improve their health.

Medications to combat obesity
Medications to combat obesity
In recent years, new medications have appeared that have proven effective and safe for the treatment of obesity. These drugs act on different mechanisms involved in the control of appetite, metabolism and thermogenesis, that is, the body's ability to burn calories.

Some of these medications are:

Liraglutide

It is an analogue of GLP-1, a hormone that is released in the intestine after eating and that stimulates insulin secretion and reduces appetite. Liraglutide is administered by subcutaneous injection once a day and has been shown to reduce body weight by an average of 8% over one year, as well as improve glucose, cholesterol and blood pressure levels.

Semaglutide

It is another GLP-1 analogue that is administered by subcutaneous injection once a week. In a recent clinical trial, semaglutide was found to produce an average weight loss of 15% over 68 weeks, the largest weight loss effect of a drug to date. In addition, it also improves metabolic and cardiovascular parameters.

Medications to combat obesity

Bupropion/naltrexone

It is a combination of two drugs that act on the central nervous system to reduce appetite and increase energy expenditure. Bupropion is an antidepressant that inhibits the reuptake of dopamine and norepinephrine, while naltrexone is an opioid receptor antagonist that blocks the pleasurable effects of food. This drug is taken orally twice a day and produces an average weight loss of 5% in a year.

Phentermine/topiramate

It is another combination of two drugs that act on the central nervous system to reduce appetite and increase the feeling of satiety. Phentermine is a stimulant that releases norepinephrine and dopamine, while topiramate is an anticonvulsant that modulates sodium and calcium channels. This drug is taken orally once a day and produces an average of 10% weight loss in one year.

Ozempic and Mounjaro

Ozempic and Mounjaro are two trade names for the same active ingredient: semaglutide, which belongs to the class of GLP-1 analogues. GLP-1 is a hormone produced in the intestine that stimulates the secretion of insulin by the pancreas when there is glucose in the blood. Additionally, GLP-1 reduces appetite and the rate of gastric emptying, which helps with weight control.

GLP-1 analogs, such as semaglutide, mimic the action of natural GLP-1, but have a longer half-life and resist degradation by enzymes. In this way, they can maintain a prolonged effect on glucose metabolism and appetite.

Ozempic and Mounjaro are administered by subcutaneous injection once a week. The initial dose is usually 0.25 mg and is gradually increased until the optimal dose is reached, which can be 0.5 mg or 1 mg depending on the case.

Medications to combat obesity

What benefits do Ozempic and Mounjaro have for patients with type 2 diabetes?

According to clinical studies carried out, these medications manage to reduce blood glucose levels (HbA1c) between 1% and 1.5%, which represents a significant improvement in glycemic control. In addition, they also manage to reduce body weight between 3 and 6 kg, which can have a positive impact on cardiovascular health and quality of life.

Ozempic and Mounjaro are safe drugs and well tolerated by most patients. The most common side effects are nausea, vomiting, diarrhea and abdominal pain, which are usually mild and temporary. In some cases, they can cause hypoglycemia (excessive drop in blood sugar), especially if combined with other antidiabetics. Therefore, it is important to adjust doses and monitor glucose levels regularly.

In conclusion, Ozempic and Mounjaro are innovative medications that offer an effective and convenient alternative for the treatment of type 2 diabetes. However, they are not a magic solution nor do they replace hygienic-dietary measures, such as following a balanced diet and exercising. physical. If you have type 2 diabetes and want to know if these drugs are right for you, consult your endocrinologist.

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